What is A2M Therapy and How Does It Protect Your Joints?

Jun 10

Protecting Your Joints Starts at the Cellular Level

When it comes to joint pain and cartilage damage, the usual go-to treatments often focus on reducing inflammation or masking pain. But what if you could actually slow down the damage and protect your joints from future wear?

At NexGenEsis Healthcare in Hawaii, one of the advanced options we offer is A2M therapy: a cutting-edge treatment that uses a protein already found in your body to help preserve joint health and reduce inflammation.

What Exactly is A2M?

A2M (Alpha-2-Macroglobulin) is a large protein naturally present in your blood. Its main job? To trap and deactivate the enzymes that break down cartilage in your joints.

In patients with osteoarthritis or joint degeneration, these harmful enzymes (called proteases) become overactive and start destroying cartilage faster than your body can repair it. That’s where A2M comes in—essentially acting like a biological “sponge,” binding to these enzymes and neutralizing them.

How Does A2M Therapy Work?

Here’s how the process works at our clinic:

A small sample of your blood is drawn.
The A2M protein is isolated and concentrated in our lab.
The concentrated A2M is then injected directly into the affected joint.

This approach gives your body targeted support to protect cartilage and may help slow down the progression of joint damage over time.

Benefits of A2M Therapy

Protects cartilage from further breakdown
Uses your body’s natural biology—no foreign substances

Minimally invasive, in-office procedure
May slow the progression of osteoarthritis
Non-surgical option for those not ready for joint replacement

It’s especially effective for:

Early to moderate osteoarthritis
Knee, hip, and shoulder joint issues
Active individuals looking to preserve joint function

    Treatment Option
    Targets Root Cause?
    Promotes Repair?
    Invasive?
    Natural?
  


    Cortisone Shot
    ❌ No
    ❌ No
    ❌ Low
    ❌ No
  

    A2M Therapy
    ✅ Yes
    ✅ Yes
    ✅ Low
    ✅ Yes
  

    Joint Replacement
    ✅ Yes (surgically)
    ❌ No (replaces)
    ❌ High
    ❌ No
  

Is A2M Therapy Right for You?

Not everyone is a candidate for A2M therapy, but that’s where a personalized consultation comes in. We’ll review your imaging, history, and joint health to determine if our treatments will give you the results you are aiming for.

Get Expert Joint Care in Hawaii

If you’re exploring non-surgical options for joint pain, A2M therapy could be the proactive step you’ve been looking for. Our team at NexGenEsis Healthcare is here to guide you through safe, science-backed treatment options to help you move and feel better.

📍 Now accepting patients across Oahu and beyond.

Kaylee Lin